BPPK

Notes added 

1. Biopharmaceutics :

  1. Introduction to Biopharmaceutics
     a. Absorption of drugs from gastrointestinal tract.
     b. Drug Distribution.
     c. Drug Elimination.

2. Pharmacokinetics :  
  2. Introduction to Pharmacokinetics.
     a. Mathematical model
     b. Drug levels in blood.
     c. Pharmacokinetic model
     d. Compartment models
     e. Pharmacokinetic study.


3. One compartment open model.      
    a. Intravenous Injection (Bolus)
    b. Intravenous infusion.

4. Multicompartment models.    
     a. Two compartment open model.
     b. IV bolus, IV infusion and oral administration

5. Multiple  Dosage Regimens.    
   a. Repititive Intravenous injections  One Compartment Open Model
   b. Repititive Extravascular dosing  One Compartment Open model
  c. Multiple Dose Regimen  Two Compartment Open Model

6.  Nonlinear Pharmacokinetics.  
      a. Introduction
      b. Factors causing Non-linearity.
      c. Michaelis-menton method of estimating parameters.

7. Noncompartmental Pharmacokinetics.  
      a. Statistical Moment Theory.
      b. MRT for various compartment models.
      c. Physiological Pharmacokinetic model.

8. Bioavailability and Bioequivalence.
   a. Introduction.
   b. Bioavailability study protocol.
   c. Methods of Assessment of Bioavailability

    PRACTICAL

1. Improvement of dissolution characteristics of slightly soluble drugs by some methods.

2.  Comparison of dissolution studies of two different marketed products of same drug.

3.  Influence of polymorphism on solubility and dissolution.

4.  Protein binding studies of a highly protein bound drug and poorly protein bound drug.

5.  Extent of plasma-protein binding studies on the same drug (i.e. highly and poorly  protein bound drug) at different concentrations in respect of constant time.  

6.  Bioavailability studies of some commonly used drugs on animal/human model.

7.  Calculation of Ka, Ke, t1/2, Cmax, AUC, AUMC, MRT etc. from blood profile data.

8.  Calculation of bioavailability from urinary excretion data for two drugs.

9.  Calculation of AUC and bioequivalence from the given data for two drugs.

10. In vitro absorption studies.

11. Bioequivalency studies on the different drugs marketed.(eg) Tetracycline, Sulphamethoxzole, Trimethoprim, Aspirin etc., on animals and human volunteers.

12. Absorption studies in animal inverted intestine using various drugs.

13. Effect on contact time on the plasma protein binding of drugs.

14. Studying metabolic pathways for different drugs based on elimination kinetics data.

15. Calculation of elimination half-life for different drugs by using urinary elimination  data and blood level data.

16. Determination of renal clearance.